Most colorectal cancers are caused due to advanced age and lifestyle factors, with only a small number of cases due to underlying genetic disorders.
Some of the risk factors include diet, obesity, smoking, and lack of physical activity. Red meat, processed meat, and alcohol increase the risk of developing colorectal cancer.The inflammatory bowel disease, which includes Crohn's disease and ulcerative colitis can also lead to colorectal cancer.
The early stages of colon cancer are restricted to the large intestine, but stage 3 cancer can spread to the lymph nodes and stage 4 can spread to other organs.
Erectile dysfunction is the common sexual dysfunction in which a man fails to obtain a firm and strong penile erection. This leads to unsatisfactory sexual life.
Men who commonly take Viagra or Sildenafil, to treat their erection problems may also be significantly reducing their risk of developing colorectal cancer, according to the findings of a study.
Colorectal cancer is one of the leading cause of death in Americans. It accounts for roughly 50,600 deaths in 2018, based on data from the American Cancer Society.
A team of Chinese researchers studied the effects of Sildenafil on human colorectal cancer cells in both laboratory and live animal testing. The results were published in a late 2015 issue of the “American Journal of Cancer Research.”
Sildenafil is a PDE-5 inhibitor, approved for use in the sexual dysfunction since the year 1998. The discovery of Sildenafil revolutionized the treatment of erectile dysfunction. It works by improving the blood supply to the penile organ. The dose of 100mg is the most effective dose for treating erectile dysfunction.
Sildenafil Inhibited Cancer Spread
The In vitro studies on the Human colorectal cancer cells treated with small amounts of Sildenafil, showed that Sildenafil
• Considerably inhibited the growth of cancer cells,
• Stopped their spread by interfering with the normal cell cycle, and
• Also induced the death of some cancer cells.
Similar observations were recorded when the laboratory mice grafted with human colorectal cancer cells were treated with the erectile dysfunction drug, Sildenafil.
The ACS reports that 4.49 percent of American men will develop colorectal cancer at some point of time during their lifetime, while 4.15 percent of American women will be diagnosed with this form of cancer. Risk factors comprise a personal history of colorectal polyps or inflammatory bowel disease, as well as a family history of colorectal polyps or cancer.
The common lifestyle-related behaviors that can lead to colorectal cancer are smoking, heavy alcohol consumption, a diet high in red meat, and obesity.